Human Sera
Akron Biotechnology LLC Human AB Serum Converted from Octaplas , Pooled Plasma (Human), Xeno-Free, Virus Inactivated, GMP Grade, 100 mL Bottle, AR1010-0100
Akron’s Human AB Serum, Converted from Octaplas, Pooled Plasma (Human), Xeno-Free, Virus Inactivated is manufactured, tested, and released following relevant cGMP guidelines for ancillary materials.Plasma Source• Octaplas is an FDA-approved, sterile, pyrogen-free, frozen, S/D treated, prion-ligand treated, pooled human plasma• Solvent Detergent (S/D) treatment for inactivation of enveloped viruses• Immune Neutralization for inactivation of certain non-enveloped viruses• Affinity Chromatography intended to reduce prion proteinsSterile microfiltration minimizes the presence of bacteria and parasites.Stability• 24-month shelf life• Store at -20 °C• Transport on dry ice• Avoid repeated freeze-thaw cyclesFor Use StatementFor research use or further manufacturing use in ex vivo cell therapy applications. This product is not intended for direct in vivo use or for direct clinical use as a drug, therapeutic, biologic, or medical device.
Cayman Chemical FenpropathrIn 50mg
A pyrethroid insecticide; a slow activator of Nav1.8; decreases the number of Colorado potato beetle (L. decemlineata) adults and third stage larvae at 0.01%; has been found in watershed sediment samples
Cayman Chemical EfonIdIpIn 100mg
An L- and T-type calcium channel inhibitor; inhibits hamster Cav1.2a and human Cav3.2 (IC50s = 1.8 and 350 nM, respectively); inhibits L- and T-type calcium channels and fetal bovine serum-induced hypertrophy in isolated mouse cardiomyocytes; increases survival in a mouse model of acute myocardial infarction induced by ligation of the left coronary artery at 200 mg/kg; inhibits SARS-CoV-2 Mpro (IC50 = 38.5 µM)
Cayman Chemical CarbamazepIn 10 11epoxIde 50mg
An active metabolite of carbamazepine; has anticonvulsant activity against maximal electroshock-induced seizures in mice; has been found in wastewater effluent
Cayman Chemical Linolenic ACD ethyl esTR 100mg
An esterified version of GLA which is less water soluble but more amenable for the formulation of GLA-containing diets
Cayman Chemical BYK 191023hydrochlorIde 50mg
A selective iNOS inhibitor (IC50s = 0.086, 17, and 162 μM for human recombinant iNOS, nNOS, and eNOS, respectively); inhibits iNOS-induced nitrite generation in RMC, RAW, and HEK293 cells (IC50s = 33, 3.1, and 13 μM, respectively); suppresses LPS-induced increases in plasma nitrate and nitrite levels in rats (ED50 = 14.9 μmol/kg per hour); prevents development of delayed hypotension in a rat model of LPS-induced endotoxemia at 50 μmol/kg per hour; increases mean arterial pressure and renal blood flow in a sheep model of septic shock
Cayman Chemical VInblastInsulfate 50mg
An antimicrotubule drug used to treat Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer; inhibits steady-state tubulin addition to microtubules (Ki = 0.18 μM) and inhibits B16 melanoma cell proliferation (IC50 = 1 nM)
Cayman Chemical ResorcInolnaphthaleIn 50mg
Increases the activity of angiotensin-converting enzyme 2 (ACE2) in vitro (EC50 = 19.5 μM)
Cayman Chemical MelItracenhydrochlorIde 100mg
A thymoleptic and tricyclic antidepressant; inhibits 5-HT uptake in rat brain synaptosomes (IC50 = 670 nM); increases the lethality of yohimbine in mice at 20 and 40 mg/kg
Cayman Chemical ARUK2001607 50mg
A PI5P4Kγ inhibitor (IC50 = 0.079 µM for PI5P4Kγ+, a construct with mutations conferring increased functional activity); selectively binds to PI5P4Kγ (Kd = 7.1 nM) over 22 other lipid kinases but does bind to PIP5K1C (Kd = 230 nM); selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >15.8 and >25.1 µM, respectively); selective for PI5P4Kγ over 138 other kinases in a kinase panel and a variety of receptors, enzymes, and ion channels in a safety panel at 10 µM but does inhibit Aurora B kinase and CLK2 by 31 and 37% and dopamine uptake by 59% at 10 µM
Cayman Chemical NtrIdecnoylLHomoserIn la 50mg
An N-acyl homoserine lactone; has been found in Y. pseudotuberculosis
Cayman Chemical Rsperdon 50mg
An atypical antipsychotic; binds to dopamine D2 receptors (Ki = 3 nM) and the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 0.12 nM); also binds to dopamine D4, α1- and α2-adrenergic, 5-HT1C, 5-HT1D, and histamine H1 receptors (Kis = 7, 0.81, 7.3, 47, 52, and 2.1 nM, respectively); attenuates deficits in prepulse inhibition of the acoustic startle response, but not deficits in social interaction, in a rat neonatal ventral hippocampal lesion model of schizophrenia at 0.1 mg/kg per day
Cayman Chemical 3-O-MethylgunosIn 100mg
An antiviral nucleoside analog; inhibits viral plaque formation and viral RNA synthesis in vaccinia virus-infected Vero cells at 10 µM
Cayman Chemical MartInostat 50mg
An HDAC inhibitor (IC50s = 0.3, 2, 0.6, and 4.1 nM for HDAC1, -2, -3, and -6, respectively); selective for these HDACs over HDAC4, -5, -7, -8, and -9 (IC50s = 1,970, 352, >20,000, >15,000, and >15,000 nM, respectively); reduces H3K9ac and H4K12ac in primary mouse neuronal cells (EC50s = 100 nM for both)